Determining the molecular basis of fungal biosynthetic enzymes and reprogramming their chemical output
A PhD scholarship is available to join our team at the Synthetic and Chemical Biology Laboratory of the Ferrier Research Institute based at Te Herenga Waka.
Project overview
We are looking for an enthusiastic and motivated PhD student to perform research towards improving our understanding of how unusual fungal enzymes catalyse unique chemistry. The candidate will determine the specific molecular details that control and deliver an unusual chemical output that unites two usually distinct groups of compounds. This knowledge will be used to reprogramme genetic sequences of these enzymes to expand the chemical diversity of this class.
The techniques that this project may use include:
- genetic manipulation of fungi
- analytical chemistry and isolation and characterisation of target compounds
- protein expression, purification, and analysis
- generation and analysis of nucleic acid and protein sequence datasets.
Experience in all of these fields is not required, as our group includes experts who can provide the necessary training. However, hands-on familiarity with standard molecular biology techniques—such as PCR and DNA cloning—is expected. Experience with LC-MS analysis or protein expression would be favourable. Importantly, candidates must be excited to learn, adapt, and develop new experimental techniques within the laboratory.
Candidate profile
Candidates should have a background in chemistry and/or molecular biology and/or protein biochemistry and must possess either a Bachelor’s degree with Honours or a Master’s degree in a relevant discipline (for example, Chemistry, Molecular Biology, Genetics, Microbiology, Biochemistry, or similar). Candidates will need a high level of literacy and numeracy, and will need to be proficient in English.
Funding and eligibility
- Stipend—NZ$35,000/year (tax-free) for 3 years + full tuition fees.
- Eligibility—Open to New Zealand and international candidates (must reside in NZ for the duration of the project).
- Entry requirements—A GPA of 7.5 or higher, First Class Honours or Master’s degree, and demonstration of English proficiency.
- Must meet PhD admission criteria at Victoria University of Wellington.
How to apply
Email Dr Alison Daines at ferrierpgc@vuw.ac.nz with:
- a cover letter outlining your interest and suitability
- your CV and academic transcript
- contact details for two referees.